Four Indian Brands (coded as A,B,C,D) of 500 mg Paracetamol tablets were evaluated for various In vitro parameters, i.e. size and shape, uniformity of weight, hardness, friability, content, disintegration time and dissolution profile. All the products met the requirements of Indian Pharmacopoeia for tablet formulation. The hardness of all the brands was found to be in the range of 3.2-5.2 kg/cm2, while friability was less than 1 %. The disintegration time of all brands was found to be in the range of 1min 30 sec to 3 min 57 sec. All brands comply the I.P. weight variation test and dissolution test. Formulation additives in the tablet, physical form of the drug used in the tablet and manufacturing process vary from manufacturer to manufacturer which is responsible for the variation in the observed dissolution profiles.
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